RESEARCHER PROFILE

Xiao‐Dong Su

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Chongqing University of Science and Technology

Enzyme Structure and FunctionProtein Structure and DynamicsCrystal structures of chemical compoundsBiochemical and Structural CharacterizationBiochemical and Molecular Research

Xiao‐Dong Su works in Enzyme Structure and Function, Protein Structure and Dynamics, Crystal structures of chemical compounds, Biochemical and Structural Characterization, Biochemical and Molecular Research. Recorded institutional associations include Chongqing University of Science and Technology, Peking University.

224Publications
9,021Citations
41H-index

Inclusion identifies researchers whose recorded research contributions may inform their university’s understanding of its research community. It does not rank individual research quality or establish current employment.

Selected research works

Up to 100 highly cited works; DOI links open the original research. Counts reflect the collected record, not real-time citation totals.

  1. Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

    2020 · 1,184 citations
  2. Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

    2018 · 856 citations
  3. RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas

    2014 · 409 citations
  4. Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

    2008 · 385 citations
  5. Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP

    2020 · 328 citations
  6. Probing Allostery Through DNA

    2013 · 293 citations
  7. Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection

    2017 · 271 citations
  8. Crystal structure of reduced protein R2 of ribonucleotide reductase: the structural basis for oxygen activation at a dinuclear iron site

    1996 · 261 citations
  9. Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy

    2020 · 249 citations
  10. Mutations on RBD of SARS-CoV-2 Omicron variant result in stronger binding to human ACE2 receptor

    2021 · 217 citations
  11. The structural basis for the sensing and binding of cyclic di-GMP by STING

    2012 · 213 citations
  12. The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase

    1994 · 204 citations
  13. Fluorescent indicators for simultaneous reporting of all four cell cycle phases

    2016 · 202 citations
  14. Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway

    2019 · 153 citations
  15. DNA binding mechanism revealed by high resolution crystal structure of Arabidopsis thaliana WRKY1 protein

    2007 · 146 citations
  16. Structural insights into immunoglobulin M

    2020 · 145 citations
  17. Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation

    2020 · 145 citations
  18. Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure

    2020 · 142 citations
  19. A variational algorithm to detect the clonal copy number substructure of tumors from scRNA-seq data

    2023 · 121 citations
  20. Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA

    2012 · 106 citations
  21. Bacillus subtilis arsenate reductase is structurally and functionally similar to low molecular weight protein tyrosine phosphatases

    2001 · 96 citations
  22. Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases

    2014 · 96 citations
  23. Identification and characterization of phosphodiesterases that specifically degrade 3′3′-cyclic GMP-AMP

    2015 · 92 citations
  24. Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self‐activation

    2010 · 91 citations
  25. Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA

    2017 · 85 citations

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