RESEARCHER PROFILE

Irina Al‐Khairi

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I

Dasman Diabetes Institute

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismLipid metabolism and disordersDiabetes, Cardiovascular Risks, and LipoproteinsObstructive Sleep Apnea Research

Irina Al‐Khairi works in Adipokines, Inflammation, and Metabolic Diseases, Adipose Tissue and Metabolism, Lipid metabolism and disorders, Diabetes, Cardiovascular Risks, and Lipoproteins, Obstructive Sleep Apnea Research. Recorded institutional associations include Dasman Diabetes Institute.

89Publications
1,810Citations
24H-index

ORCID

Inclusion identifies researchers whose recorded research contributions may inform their university’s understanding of its research community. It does not rank individual research quality or establish current employment.

Selected research works

Up to 100 highly cited works; DOI links open the original research. Counts reflect the collected record, not real-time citation totals.

  1. Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance

    2015 · 126 citations

  2. Previous COVID-19 Infection and Antibody Levels After Vaccination

    2021 · 99 citations

  3. Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D

    2016 · 99 citations

  4. The multi-faces of Angptl8 in health and disease: Novel functions beyond lipoprotein lipase modulation

    2020 · 93 citations

  5. Robust Antibody Levels in Both Diabetic and Non-Diabetic Individuals After BNT162b2 mRNA COVID-19 Vaccination

    2021 · 92 citations

  6. Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity

    2013 · 90 citations

  7. Circulating ANGPTL8/Betatrophin Is Increased in Obesity and Reduced after Exercise Training

    2016 · 86 citations

  8. Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin

    2019 · 82 citations

  9. Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome

    2016 · 76 citations

  10. Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone

    2016 · 64 citations

  11. Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension

    2018 · 63 citations

  12. MAP kinase phosphatase DUSP1 is overexpressed in obese humans and modulated by physical exercise

    2014 · 60 citations

  13. DNAJB3/HSP-40 Cochaperone Is Downregulated in Obese Humans and Is Restored by Physical Exercise

    2013 · 59 citations

  14. Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans

    2014 · 51 citations

  15. Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue

    2014 · 49 citations

  16. ANGPTL4: A Predictive Marker for Diabetic Nephropathy

    2019 · 41 citations

  17. Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects

    2015 · 40 citations

  18. Novel G6B gene variant causes familial autosomal recessive thrombocytopenia and anemia

    2016 · 37 citations

  19. DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression

    2015 · 34 citations

  20. Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are increased in obesity and reduced after physical exercise

    2017 · 32 citations

  21. Reduced miR-181d level in obesity and its role in lipid metabolism via regulation of ANGPTL3

    2019 · 29 citations

  22. Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study

    2020 · 25 citations

  23. Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea

    2018 · 25 citations

  24. Increased Circulation and Adipose Tissue Levels of DNAJC27/RBJ in Obesity and Type 2-Diabetes

    2018 · 24 citations

  25. Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and Obesity

    2021 · 22 citations

  26. Serological Response to BNT162b2 and ChAdOx1 nCoV-19 Vaccines in Patients with Inflammatory Bowel Disease on Biologic Therapies

    2021 · 21 citations

  27. Remyelination modulators in multiple sclerosis patients

    2017 · 21 citations

  28. Effect of sleeve gastrectomy on the expression of meteorin-like (METRNL) and Irisin (FNDC5) in muscle and brown adipose tissue and its impact on uncoupling proteins in diet-induced obesity rats

    2020 · 19 citations

  29. Enhanced α1 adrenergic sensitivity in sensorimotor gating deficits in neonatal ventral hippocampus-lesioned rats

    2008 · 19 citations

  30. Targeted Metabolomics Analysis on Obstructive Sleep Apnea Patients after Multilevel Sleep Surgery

    2020 · 18 citations

  31. Higher Levels of ANGPTL5 in the Circulation of Subjects With Obesity and Type 2 Diabetes Are Associated With Insulin Resistance

    2019 · 18 citations

  32. Dysregulated Urinary Extracellular Vesicle Small RNAs in Diabetic Nephropathy: Implications for Diagnosis and Therapy

    2024 · 17 citations

  33. Investigating the Role of FABP4 in Diabetes and Obesity and the Influence of Age and Ethnicity: A Comprehensive Analysis of a Cohort from the KEDP-Study

    2024 · 17 citations

  34. Changes in the expression of meteorin‐like ( METRNL ), irisin ( FNDC5 ), and uncoupling proteins ( UCPs ) after bariatric surgery

    2022 · 16 citations

  35. Association of significantly elevated plasma levels of NGAL and IGFBP4 in patients with diabetic nephropathy

    2022 · 16 citations

  36. Potential Role of N-Cadherin in Diagnosis and Prognosis of Diabetic Nephropathy

    2022 · 15 citations

  37. Increased Levels of Circulating IGFBP4 and ANGPTL8 with a Prospective Role in Diabetic Nephropathy

    2023 · 13 citations

  38. Investigating the Role of GDF-15 in Diabetes and Obesity: A Comprehensive Analysis of a Cohort from the KDEP Study

    2025 · 10 citations

  39. Effect of Dual Glucagon-Like Peptide 1/Glucose-Dependent Insulinotropic Polypeptide Receptor Agonist (Tirzepatide) versus Bariatric Surgery on Weight Loss and Nonalcoholic Fatty Liver Disease

    2024 · 10 citations

  40. Adipocyte Angptl8 deletion improves glucose and energy metabolism and obesity associated inflammation in mice

    2024 · 8 citations

  41. Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait

    2024 · 7 citations

  42. The Rise of IGFBP4 in People with Obstructive Sleep Apnea and Multilevel Sleep Surgery Recovers Its Basal Levels

    2021 · 7 citations

  43. Increased expression level of ANGPTL8 in white adipose tissue under acute and chronic cold treatment

    2021 · 7 citations

  44. Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling

    2024 · 6 citations

  45. Effect of pioglitazone on inflammatory response and clinical outcome in T2DM patients with COVID-19: a randomized multicenter double-blind clinical trial

    2024 · 5 citations

  46. Early autoantibody screening for type 1 diabetes: a Kuwaiti perspective on the advantages of multiplexing chemiluminescent assays

    2023 · 5 citations

  47. Plasma insulin is required for the increase in plasma angiopoietin‐like protein 8 in response to nutrient ingestion

    2023 · 5 citations

  48. Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity

    2022 · 5 citations

  49. Altered expression and alpha‐1 adrenergic receptor mediated activity of protein kinase C in the prefrontal cortex of rats with neonatal ventral hippocampus lesions

    2009 · 5 citations

  50. Angiopoietin-2 and Angiopoietin-like Proteins with a Prospective Role in Predicting Diabetic Nephropathy

    2024 · 4 citations

  51. ANGPTL3 Variants Associate with Lower Levels of Irisin and C-Peptide in a Cohort of Arab Individuals

    2021 · 4 citations

  52. Follistatin-like 1: a novel biomarker with a potential link to obstructive sleep apnea severity and treatment efficacy

    2025 · 2 citations

  53. Circulating ORM2 as a Biomarker of Metabolic Dysfunction: Evidence from the KADEM Study in Kuwaiti Adults

    2025 · 2 citations

  54. Elevated IGFBP4 and Cognitive Impairment in a PTFE-Induced Mouse Model of Obstructive Sleep Apnea

    2025 · 2 citations

  55. 208-OR: Comparable Improvement in NAFLD, Weight Loss, and Lipid Metabolism in Rats Treated with Dual GLP-1–GIP Receptor Agonist (Tirzepatide) and Gastric Sleeve

    2023 · 2 citations

  56. Association of COVID-19 Vaccines ChAdOx1-S and BNT162b2 with Circulating Levels of Coagulation Factors and Antithrombin

    2022 · 2 citations

  57. GALNT2 rs4846914 SNP Is Associated with Obesity, Atherogenic Lipid Traits, and ANGPTL3 Plasma Level

    2022 · 2 citations

  58. Elevated IGFBP4 and Cognitive Impairment in a PTFE-Induced Mouse Model of Obstructive Sleep Apnea

    2025 · 1 citations

  59. 1586-P: Association between PCSK7 Levels and NAFLD Severity in KADEM Study

    2024 · 1 citations

  60. Increased Plasma Level of IGFBP4 in Obstructive Sleep Apnea Patients and the Restoration of its level Through Multilevel Sleep Surgery

    2020 · 1 citations

  61. Associations of Elevated Lipoprotein(a) with C-Reactive Protein and Type 2 Diabetes in a Multiethnic Population

    2026 · 0 citations

  62. Circulating IGFBP-7 in Obstructive Sleep Apnea: A Single-Cohort Preliminary Assessment of Its Diagnostic Performance and Post-Treatment Dynamics

    2026 · 0 citations

  63. Osteoactivin/GPNMB as a candidate biomarker of diabetic nephropathy in type 2 diabetes: associations with angiogenic and kidney injury biomarkers

    2026 · 0 citations

  64. Impact of Tumor Necrosis Factor Antagonist Therapy on Circulating Angiopoietin-like Protein 8 (ANGPTL8) Levels in Crohn’s Disease—A Prospective Multi-Center Study

    2025 · 0 citations

  65. 1691-P: Effects of Obstructive Sleep Apnoea on Cognitive Function and Behaviour—Insight from an Innovative C57BL/6 Mouse Model

    2025 · 0 citations

  66. P0893 Angiopoietin-like Protein 8 (ANGPTL8) in Inflammatory Bowel Disease and Its Response to Anti-TNFα Therapy; A Prospective Multi Center Study

    2025 · 0 citations

  67. IGFBPS IN OBSTRUCTIVE SLEEP APNEA, AN ANIMAL MODEL STUDY

    2024 · 0 citations

  68. 301-OR: Synergistic Effects of Dapagliflozin and Tirzepatide Combination Treatment on Weight Loss and Glucose Regulation in Diet-Induced Obese Animals

    2024 · 0 citations

  69. 123-OR: MiR103 as a Potential Inhibitor for Dyslipidemia through Modulation of ANGPTL8 Level

    2024 · 0 citations

  70. Ethnic Variations in the Levels of Bone Biomarkers (Osteoprostegerin, Receptor Activator of Nuclear Factor Kappa-Β Ligand and Glycoprotein Non-Metastatic Melanoma Protein B) in People with Type 2 Diabetes

    2024 · 0 citations

  71. Investigating the role of GDF-15 in diabetes and obesity: A comprehensive analysis of a cohort from the KEDP-study

    2024 · 0 citations

  72. Adipose Angptl8 Controls Glucose and Energy Metabolism and its Suppression in Mice Improves Diet Induced Obesity and Inflammation

    2024 · 0 citations

  73. Abstract #1604668: Insulin-Like Growth Factor Binding Protein 4 Increases Under Stressful Conditions of Transient Oxygen Deprivation

    2023 · 0 citations

  74. 5-OR: Adipocyte ANGPTL8 Regulates Insulin Sensitivity and Thermogenic Programing

    2023 · 0 citations

  75. Increased Glucagon Immunoreactivity in a Rat Model of Diet-Induced Obesity following Sleeve Gastrectomy

    2023 · 0 citations

  76. Supplementary Material for: Increased Glucagon Immunoreactivity in a Rat Model of Diet-induced Obesity following Sleeve Gastrectomy

    2023 · 0 citations

  77. The association between biomarker angiopoietin-like protein five and obstructive sleep apnea in patients undergoing bariatric surgery

    2022 · 0 citations

  78. Association of significantly elevated serum levels of NGAL and IGFBP4 in patients with diabetic nephropathy

    2021 · 0 citations

  79. Increased expression level of ANGPTL8 in White Adipose tissue under Chronic Cold Treatment

    2021 · 0 citations

  80. Association between Bone Biomarkers Osteoactivin and OPG with Plasma Levels of Irisin and Meteorin-like Protein in People with T2D and Obesity

    2021 · 0 citations

  81. Abstract # P-21: Increased Plasma Level of ANGPTL3, 4 and 8 in Obesity and T2D

    2016 · 0 citations

  82. Abstract # OR-17: Increased Circulation Level of Angptl8/Betatrophin and Angptl4 in Hypertension

    2016 · 0 citations

  83. P042 Multiplexed analysis of inflammatory, metabolic and stress markers in obese subjects before and after a defined exercise program

    2012 · 0 citations

  84. Association of obesity with down-regulation of heat shock protein 40 expression and evidence that exercise retrieves its normal expression

    2012 · 0 citations

  85. Characterization of signal transduction pathways of alpha-1 adrenergic receptors in neonatal ventral hippocampus lesion rat model

    2007 · 0 citations

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