RESEARCHER PROFILE

Mikhail Krasavin

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Immanuel Kant Baltic Federal University

Crystal structures of chemical compoundsCrystallography and molecular interactionsCrystal Structures and PropertiesMulticomponent Synthesis of HeterocyclesSynthesis and biological activity

Mikhail Krasavin works in Crystal structures of chemical compounds, Crystallography and molecular interactions, Crystal Structures and Properties, Multicomponent Synthesis of Heterocycles, Synthesis and biological activity. Recorded institutional associations include Immanuel Kant Baltic Federal University, St Petersburg University, Ghent University.

703Publications
6,517Citations
36H-index

ORCID

Inclusion identifies researchers whose recorded research contributions may inform their university’s understanding of its research community. It does not rank individual research quality or establish current employment.

Selected research works

Up to 100 highly cited works; DOI links open the original research. Counts reflect the collected record, not real-time citation totals.

  1. Spirocyclic Scaffolds in Medicinal Chemistry

    2020 · 618 citations

  2. Spirocyclic Motifs in Natural Products

    2019 · 247 citations

  3. Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

    2015 · 141 citations

  4. Antimalarial, Antiproliferative, and Antitumor Activities of Artemisinin-Derived, Chemically Robust, Trioxane Dimers

    1999 · 125 citations

  5. Modern Trends of Organic Chemistry in Russian Universities

    2018 · 87 citations

  6. Multicomponent reactions of isocyanides in the synthesis of heterocycles

    2010 · 84 citations

  7. Multi-component reactions between 2-aminopyrimidine, aldehydes and isonitriles: the use of a nonpolar solvent suppresses formation of multiple products

    2005 · 80 citations

  8. Complexity-Enhancing Acid-Promoted Rearrangement of Tricyclic Products of Tandem Ugi 4CC/Intramolecular Diels−Alder Reaction

    2006 · 75 citations

  9. Carbonic Anhydrase IX Inhibitors as Candidates for Combination Therapy of Solid Tumors

    2021 · 71 citations

  10. Current diversity of cyclic anhydrides for the Castagnoli–Cushman-type formal cycloaddition reactions: prospects and challenges

    2016 · 67 citations

  11. Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment

    2018 · 67 citations

  12. New Heterocyclic Product Space for the Castagnoli–Cushman Three-Component Reaction

    2015 · 66 citations

  13. Biologically active compounds based on the privileged 2-imidazoline scaffold: The world beyond adrenergic/imidazoline receptor modulators

    2014 · 63 citations

  14. A ‘sulfonyl-azide-free’ (SAFE) aqueous-phase diazo transfer reaction for parallel and diversity-oriented synthesis

    2019 · 61 citations

  15. The Role of the Thioredoxin Detoxification System in Cancer Progression and Resistance

    2022 · 61 citations

  16. Imidazo[1,2- a ]quinoxalines Accessed via Two Sequential Isocyanide-Based Multicomponent Reactions

    2009 · 60 citations

  17. Antimalarial Simplified 3-Aryltrioxanes: Synthesis and Preclinical Efficacy/Toxicity Testing in Rodents

    2001 · 58 citations

  18. Mechanism of generation of closo -decaborato amidrazones. Intramolecular non-covalent B–H⋯π(Ph) interaction determines stabilization of the configuration around the amidrazone CN bond

    2018 · 58 citations

  19. Probing the ‘bipolar’ nature of the carbonic anhydrase active site: Aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms

    2015 · 56 citations

  20. One-Step Assembly of Carbamoyl-Substituted Heteroannelated [1,4]Thiazepines

    2006 · 54 citations

  21. Heterocyclic periphery in the design of carbonic anhydrase inhibitors: 1,2,4-Oxadiazol-5-yl benzenesulfonamides as potent and selective inhibitors of cytosolic hCA II and membrane-bound hCA IX isoforms

    2017 · 52 citations

  22. Gold‐Catalyzed Oxidation of Internal Alkynes into Benzils and its Application for One‐Pot Synthesis of Five‐, Six‐, and Seven‐Membered Azaheterocycles

    2019 · 51 citations

  23. Thioredoxin reductase inhibitors: updated patent review (2017-present)

    2021 · 47 citations

  24. Rh(II)-Catalyzed Spirocyclization of α-Diazo Homophthalimides with Cyclic Ethers

    2019 · 44 citations

  25. 1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer

    2019 · 42 citations

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