RESEARCHER PROFILE

Albert J. R. Heck

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A

Utrecht University

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and ApplicationsMetabolomics and Mass Spectrometry StudiesProtein Structure and DynamicsMonoclonal and Polyclonal Antibodies Research

Albert J. R. Heck works in Advanced Proteomics Techniques and Applications, Mass Spectrometry Techniques and Applications, Metabolomics and Mass Spectrometry Studies, Protein Structure and Dynamics, Monoclonal and Polyclonal Antibodies Research. Recorded institutional associations include Utrecht University, Netherlands Proteomics Centre.

1,316Publications
71,104Citations
131H-index

ORCID

Inclusion identifies researchers whose recorded research contributions may inform their university’s understanding of its research community. It does not rank individual research quality or establish current employment.

Selected research works

Up to 100 highly cited works; DOI links open the original research. Counts reflect the collected record, not real-time citation totals.

  1. The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

    2013 · 1,672 citations

  2. Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics

    2009 · 1,357 citations

  3. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

    2011 · 1,272 citations

  4. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

    2012 · 998 citations

  5. Selective Isolation at the Femtomole Level of Phosphopeptides from Proteolytic Digests Using 2D-NanoLC-ESI-MS/MS and Titanium Oxide Precolumns

    2004 · 891 citations

  6. Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

    2012 · 889 citations

  7. Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

    2014 · 796 citations

  8. Next-generation proteomics: towards an integrative view of proteome dynamics

    2012 · 782 citations

  9. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

    2012 · 772 citations

  10. The minimum information about a proteomics experiment (MIAPE)

    2007 · 766 citations

  11. Native mass spectrometry: a bridge between interactomics and structural biology

    2008 · 762 citations

  12. Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

    2019 · 729 citations

  13. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

    2017 · 695 citations

  14. Quantitative Phosphoproteomics of Early Elicitor Signaling in Arabidopsis

    2007 · 676 citations

  15. Native Mass Spectrometry: What is in the Name?

    2016 · 598 citations

  16. Investigation of intact protein complexes by mass spectrometry

    2004 · 583 citations

  17. Structural basis for CRISPR RNA-guided DNA recognition by Cascade

    2011 · 562 citations

  18. High-Resolution Native Mass Spectrometry

    2021 · 506 citations

  19. Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry

    2015 · 468 citations

  20. Six alternative proteases for mass spectrometry–based proteomics beyond trypsin

    2016 · 464 citations

  21. Ion mobility mass spectrometry of proteins and proteinassemblies

    2009 · 462 citations

  22. Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

    2008 · 458 citations

  23. RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions

    2011 · 449 citations

  24. Toward a Comprehensive Characterization of a Human Cancer Cell Phosphoproteome

    2012 · 434 citations

  25. NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

    2015 · 430 citations

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