RESEARCHER PROFILE
Virginijus Šikšnys
V
Vilnius University
Virginijus Šikšnys works in CRISPR and Genetic Engineering, DNA and Nucleic Acid Chemistry, Bacterial Genetics and Biotechnology, Enzyme Structure and Function, RNA regulation and disease. Recorded institutional associations include Vilnius University.
235Publications
14,519Citations
48H-index
Inclusion identifies researchers whose recorded research contributions may inform their university’s understanding of its research community. It does not rank individual research quality or establish current employment.
Selected research works
Up to 100 highly cited works; DOI links open the original research. Counts reflect the collected record, not real-time citation totals.
Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
2012 · 2,766 citationsEvolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants
2019 · 2,385 citationsThe Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli
2011 · 834 citationsA cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems
2017 · 472 citationsDirect observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes
2014 · 453 citationsCas3 is a single‐stranded DNA nuclease and ATP‐dependent helicase in the CRISPR/Cas immune system
2011 · 440 citationsTransposon-associated TnpB is a programmable RNA-guided DNA endonuclease
2021 · 359 citationsPAM recognition by miniature CRISPR–Cas12f nucleases triggers programmable double-stranded DNA target cleavage
2020 · 349 citationsProgrammable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus
2014 · 275 citationsStreptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome
2015 · 254 citationscrRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilus
2013 · 243 citationsSpatiotemporal Control of Type III-A CRISPR-Cas Immunity: Coupling DNA Degradation with the Target RNA Recognition
2016 · 241 citationsIn vitro reconstitution of Cascade‐mediated CRISPR immunity in Streptococcus thermophilus
2013 · 229 citationsRapid characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements
2015 · 225 citationsMultiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion
2022 · 205 citationsA catalogue of biochemically diverse CRISPR-Cas9 orthologs
2020 · 177 citationsStructure of the tetrameric restriction endonuclease NgoMIV in complex with cleaved DNA.
2000 · 161 citationsDirectional R-Loop Formation by the CRISPR-Cas Surveillance Complex Cascade Provides Efficient Off-Target Site Rejection
2015 · 159 citationsDiscrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor
2021 · 158 citationsAn AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis
2023 · 132 citationsType III CRISPR-Cas Immunity: Major Differences Brushed Aside
2016 · 126 citationsShort prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion
2022 · 124 citationsMiniature type V-F CRISPR-Cas nucleases enable targeted DNA modification in cells
2021 · 118 citationsMolecular mechanisms of CRISPR-mediated microbial immunity
2013 · 117 citationsTnpB structure reveals minimal functional core of Cas12 nuclease family
2023 · 107 citations