RESEARCHER PROFILE
Peter C. Tyler
← Back to Victoria University of Wellington
P
Victoria University of Wellington
Peter C. Tyler works in Biochemical and Molecular Research, Carbohydrate Chemistry and Synthesis, Chemical Reaction Mechanisms, Organic Chemistry Synthesis Methods, Crystal structures of chemical compounds. Recorded institutional associations include Victoria University of Wellington, Ferrier Research Institute.
311Publications
6,628Citations
49H-index
Inclusion identifies researchers whose recorded research contributions may inform their university’s understanding of its research community. It does not rank individual research quality or establish current employment.
Selected research works
Up to 100 highly cited works; DOI links open the original research. Counts reflect the collected record, not real-time citation totals.
One-Third-the-Sites Transition-State Inhibitors for Purine Nucleoside Phosphorylase
1998 · 246 citationsImmucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes
2001 · 192 citationsTransition State Structure of Purine Nucleoside Phosphorylase and Principles of Atomic Motion in Enzymatic Catalysis,
2000 · 190 citationsLiposomal delivery of antigen to human dendritic cells
2003 · 184 citationsThe 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor.
1999 · 157 citationsFemtomolar Transition State Analogue Inhibitors of 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli
2005 · 143 citationsThe 2.0 Å Structure of Malarial Purine Phosphoribosyltransferase in Complex with a Transition-State Analogue Inhibitor ,
1999 · 131 citationsAchieving the Ultimate Physiological Goal in Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase
2003 · 124 citationsTargeting a Novel Plasmodium falciparum Purine Recycling Pathway with Specific Immucillins
2004 · 118 citationsPurine-less Death in Plasmodium falciparumInduced by Immucillin-H, a Transition State Analogue of Purine Nucleoside Phosphorylase
2002 · 115 citationsPlasmodium falciparum Purine Nucleoside Phosphorylase
2004 · 112 citationsTransition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases.
1999 · 99 citationsAzetidine Based Transition State Analogue Inhibitors of N-Ribosyl Hydrolases and Phosphorylases
2008 · 97 citationsTransition State Analogue Inhibitors of Purine Nucleoside Phosphorylase from Plasmodium falciparum
2002 · 94 citationsSynthesis of Second-Generation Transition State Analogues of Human Purine Nucleoside Phosphorylase
2003 · 93 citationsAddition of Lithiated 9-Deazapurine Derivatives to a Carbohydrate Cyclic Imine: Convergent Synthesis of the Aza-C-nucleoside Immucillins
2001 · 91 citationsProstaglandin E2-bisphosphonate conjugates: potential agents for treatment of osteoporosis
1999 · 91 citationsMannosylated liposomes as antigen delivery vehicles for targeting to dendritic cells
2006 · 88 citationsSynthesis of a Targeted Library of Heparan Sulfate Hexa‐ to Dodecasaccharides as Inhibitors of β‐Secretase: Potential Therapeutics for Alzheimer’s Disease
2013 · 88 citationsExploring Structure−Activity Relationships of Transition State Analogues of Human Purine Nucleoside Phosphorylase
2003 · 84 citationsFour generations of transition-state analogues for human purine nucleoside phosphorylase
2010 · 82 citationsSynthesis of Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase and N-Riboside Hydrolases
2000 · 80 citationsIminoribitol Transition State Analogue Inhibitors of Protozoan Nucleoside Hydrolases
1999 · 77 citationsStructural Rationale for the Affinity of Pico- and Femtomolar Transition State Analogues of Escherichia coli 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase
2005 · 75 citationsPicomolar Transition State Analogue Inhibitors of Human 5‘-Methylthioadenosine Phosphorylase and X-ray Structure with MT-Immucillin-A
2003 · 74 citations